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Psoriasis is a chronic, immune-mediated inflammatory skin disorder characterized by hyperproliferation of keratinocytes, excessive immune activation, and systemic inflammation. Conventional treatments primarily focus on symptom management using corticosteroids, immunosuppressants, and biologics, often leading to relapse and side effects. Ayurveda classifies psoriasis under Kushtha and attributes its pathogenesis to vitiation of Vata, Pitta, and Kapha doshas, leading to metabolic dysfunction and toxin accumulation. Among Ayurvedic treatments, Virechana, a therapeutic purgation procedure in Panchakarma, is considered highly effective for Pitta-Kapha disorders, including psoriasis. Virechana aims to expel accumulated doshas, thereby detoxifying the body, modulating immune function, and restoring systemic balance.

This review critically examines the role of Virechana in psoriasis management by synthesizing Ayurvedic classical references and contemporary scientific evidence. It explores its immunomodulatory effects, detoxification mechanisms, and clinical efficacy. Modern research suggests that Virechana reduces inflammatory cytokine levels, modulates gut microbiota, and enhances skin homeostasis, making it a promising adjunct therapy for psoriasis. Furthermore, it impacts systemic oxidative stress and improves gut-skin axis regulation, which is crucial in chronic inflammatory disorders. This article aims to provide a comprehensive understanding of Virechana’s therapeutic potential in psoriasis and highlights the need for integrative clinical research to establish standardized treatment protocols.

KEYWORDS

Ayurveda, chronic inflammation, detoxification, immune modulation, Kushtha, Panchakarma, Pitta dosha, psoriasis, skin homeostasis, Vata dosha, Virechana