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Seborrheic dermatitis (SD) and androgenic alopecia (AGA) are two prevalent scalp conditions that significantly impact hair health. SD is a chronic inflammatory disorder characterized by erythema, scaling, and itching, primarily in sebaceous gland-rich areas (1). AGA, commonly known as male or female pattern baldness, is a hereditary condition driven by dihydrotestosterone (DHT)-mediated follicular miniaturization (2). Although these conditions are distinct, emerging research indicates a potential interplay between them. SD-induced inflammation, increased sebum production, and Malassezia colonization may exacerbate AGA by disrupting the hair growth cycle (3). Furthermore, oxidative stress and immune dysregulation in SD can accelerate follicular miniaturization (4). This article explores the pathophysiological links between SD and AGA, emphasizing inflammation, sebaceous activity, and microbial involvement. Understanding this relationship is crucial for developing integrated treatment strategies. Current therapeutic approaches, including antifungals, corticosteroids, and systemic antiandrogens, show promise in managing both conditions (5). However, more research is needed to establish targeted interventions. By addressing SD-related inflammation and sebum dysregulation, it may be possible to mitigate AGA progression, offering better outcomes for patients experiencing both conditions. This review synthesizes existing literature, highlights key findings, and proposes future research directions to enhance clinical management of SD and AGA.

KEYWORDS
Alopecia, androgenic alopecia, inflammation, Malassezia, pathophysiology, scalp disorders, sebaceous glands, seborrheic dermatitis, sebum, treatment